in our approach to targeting mast cells for the treatment of inflammatory diseases
Our current research and development efforts are focused on inflammatory diseases of the skin, airway, and gastrointestinal tract. These diseases collectively affect millions of people worldwide, and in their most severe forms, are associated with significant morbidity and mortality risk.
Mast cells are part of the immune system and act as a primary effector cell of certain inflammatory diseases, such as chronic urticaria. Current approaches to treating mast cell-mediated inflammation are mechanistically limited. These approaches target either specific upstream activators or downstream mediators of mast cell activity, leaving multiple, residual signaling pathways open to propagate the inflammatory response.
Targeting mast cells directly through highly selective inhibition of KIT represents a novel therapeutic approach and holds the potential to provide meaningful clinical benefit across a range of inflammatory diseases.
