cell-driven inflammation
Third Harmonic Bio is a biopharmaceutical company with a singular purpose: To advance a new treatment approach for people living with inflammatory diseases, which can take a significant toll on health and well-being.
We are currently focused on developing THB335, a highly selective, oral small molecule wild-type KIT inhibitor.
THB335 is expected to enter clinical trials during the first half of 2024. We intend to pursue development of TBH335 for chronic urticaria, a dermatologic disease affecting up to 1% of the population that is driven by mast cell activation and results in red, itchy, painful welts or hives that can severely impact patients’ quality of life, as well as for other mast cell-mediated inflammatory diseases.
Third Harmonic Bio is led by an executive team with a proven track record of building great companies, developing impactful medicines, and delivering value to their patients, employees, and shareholders.
Natalie Holles
Edward R. Conner, M.D.
Julie Person
Natalie is Chief Executive Officer (CEO) of Third Harmonic Bio. She has more than 20 years of executive leadership, business development, corporate strategy, and commercial experience gained in a range of therapeutic areas.
Prior to Third Harmonic Bio, Natalie served as President and CEO of Audentes, an Astellas company. She joined the company as Senior Vice President (SVP) and Chief Operating Officer (COO) in August 2015 and was subsequently promoted to President and COO in May 2018, and then to President and CEO in January 2020. Prior to joining Audentes, Natalie served as SVP, Corporate Development at Hyperion Therapeutics, Inc. (acquired by Horizon Pharma in 2015). Before that, she provided executive-level strategy and business development advisory services to a number of privately held biopharmaceutical companies. Earlier in her career, Natalie served as Vice President, Business Development at KAI Pharmaceuticals, Inc. (acquired by Amgen in 2012) and held corporate development and commercial roles at InterMune, Inc. (acquired by Roche in 2014) and Genentech, Inc.
Natalie holds an A.B. in human biology from Stanford University and an M.A. in molecular, cellular, and developmental biology from the University of Colorado, Boulder, where she was a Howard Hughes Medical Institute predoctoral fellow.
Edward is the Chief Medical Officer (CMO) of Third Harmonic Bio where he oversees the clinical development strategy for the company. Edward has extensive experience in clinical development, translational medicine, and clinical strategy, including broad experience in early- to late-stage and post-marketing products.
Edward joined Third Harmonic Bio from Locanabio, where he served as CMO. Prior to Locanabio, Edward was Site Lead and Division Head of Medical and Development for Astellas Gene Therapies (formerly Audentes Therapeutics). Prior to Astellas’ acquisition of Audentes, he served as CMO and Senior Vice President of Audentes Therapeutics, where he led functions including clinical development and operations, medical affairs, regulatory, drug safety, and patient advocacy. Before Audentes, Edward served as CMO of Sangamo Therapeutics. Earlier in his career, he was a Medical Director at Genentech, Inc. (now a member of the Roche Group) where he led clinical development programs for XOLAIR® (omalizumab) for the treatment of chronic urticaria and allergic asthma.
Edward earned a M.D. from the University of California, San Francisco, completed his residency in Internal Medicine at the University of Michigan and his fellowship in Clinical Immunology and Allergic Diseases at Johns Hopkins School of Medicine. He earned a B.S. degree in biology from Duke University.
XOLAIR® is a registered trademark of Novartis AG.
Julie Person is the Chief Administrative Officer at Third Harmonic Bio. She brings more than 20 years of experience in building biopharma organizations that align people practices with strategy to drive successful outcomes for patients and teams. In her role, Julie oversees human resources, corporate communications, and facilities.
Julie joined Third Harmonic Bio from Neumora Therapeutics, where she served as Chief People Officer and oversaw human resources and internal communications. Prior to Neumora, she was Head of Human Resources at Audentes Therapeutics and Sangamo Therapeutics, Inc. Prior to Sangamo, Julie was the Global Head of Talent Management at Shire Plc, where she played a key role in the integrations of both Baxalta International Inc. to Shire, and Shire into Takeda Pharmaceutical Company Ltd. Prior to Shire, she spent 12 years at McKesson Corp. in various HR roles of increasing responsibility.
Julie received her undergraduate degree in communications from Saint Mary’s College of California and completed the University of Michigan Ross School of Business Executive Leadership Program.
David Bonita, M.D.
Michael Gladstone
Natalie Holles
Mark Iwicki (Chairman)
Rob Perez
Martin Seidel, Ph.D.
Thomas M. Soloway
Natalie is Chief Executive Officer of Third Harmonic Bio. She has more than 20 years of executive leadership, business development, corporate strategy, and commercial experience gained in a range of therapeutic areas.
Prior to Third Harmonic, Natalie served as President and Chief Executive Officer of Audentes, an Astellas company. She joined the company as Senior Vice President and Chief Operating Officer in August 2015 and was subsequently promoted to President and Chief Operating Officer in May 2018, and then to President and Chief Executive Officer in January 2020. Prior to joining Audentes, Natalie served as Senior Vice President, Corporate Development at Hyperion Therapeutics, Inc. (acquired by Horizon Pharma in 2015). Before that, she provided executive-level strategy and business development advisory services to a number of privately held biopharmaceutical companies. Earlier in her career, Natalie served as Vice President, Business Development at KAI Pharmaceuticals, Inc. (acquired by Amgen in 2012) and held corporate development and commercial roles at InterMune, Inc. (acquired by Roche in 2014) and Genentech, Inc.
Natalie holds an A.B. in human biology from Stanford University and an M.A. in molecular, cellular and developmental biology from the University of Colorado, Boulder, where she was a Howard Hughes Medical Institute predoctoral fellow.