Cambridge, Mass. — (BUSINESSWIRE) — June 28, 2022 – Third Harmonic Bio, a clinical-stage biopharmaceutical company developing a potent, highly selective, oral KIT inhibitor for the treatment of severe allergy and inflammation, today announced the appointment of Julie Person to chief administrative officer. Ms. Person brings more than 20 years of experience in building biopharma organizations that align people practices with strategy to drive successful outcomes for patients and teams. In her role, Ms. Person will hold leadership responsibilities for human resources, corporate communications and facilities.

“I am delighted to welcome Julie to the team to lead our efforts around organizational development as Third Harmonic scales and our work advances,” said Natalie Holles, chief executive officer of Third Harmonic Bio. “We are passionate about building a company that provides the infrastructure, support and growth opportunities to our team that are essential to driving optimal performance as we advance THB001 for the treatment of urticaria and other inflammatory diseases.”

“Behind the incredible science at Third Harmonic Bio are the talented and committed employees dedicated to advancing the next wave of medicine for allergy and inflammation,” said Ms. Person. “I look forward to working with Natalie and the rest of the management team to build a great culture that aligns our operating principles with our goals for the company and for THB001.”

Ms. Person joins the Company from Neumora Therapeutics, where she served as chief people officer and oversaw human resources and internal communications. Prior to Neomora, she was head of human resources at Audentes Therapeutics and Sangamo Therapeutics, Inc. Prior to Sangamo, Ms. Person was the global head of talent management at Shire Plc., where she played a key role in the integrations of both Baxalta International Inc. to Shire, and Shire into Takeda Pharmaceutical Company Ltd. Prior to Shire, she spent 12 years at McKesson Corp. in various HR roles of increasing responsibility.

Ms. Person received her undergraduate degree in communications from Saint Mary’s College of California and completed the University of Michigan Ross School of Business Executive Leadership Program.

About Third Harmonic Bio
Third Harmonic Bio is a clinical-stage biopharmaceutical company focused on advancing the next wave of medicine for allergy and inflammation. The company’s lead product candidate, THB001, is a highly selective, oral small-molecule inhibitor of KIT, a cell surface receptor that serves as the master regulator of mast cell function and survival. The company is in a Phase 1a clinical trial in healthy volunteers for THB001 and anticipates initiating a Phase 1b proof-of-concept study in cold-inducible urticaria during the second half of 2022. With promising drug-like properties and an encouraging early clinical profile, THB001 has the potential to revolutionize the treatment of a broad range of dermatologic, respiratory and gastrointestinal allergic and mast-cell-mediated inflammatory diseases. Visit ThirdHarmonicBio.com or follow us on Twitter or LinkedIn to learn more about our work, team, and culture.

Media Contact:
Lori Murray
lori.murray@captivate-comms.com

Investor Contact:
Bob Ho
rho@thirdharmonicbio.com

Brings Significant Allergy and Inflammatory Disease Clinical Development Experience, Including in Urticaria and Allergic Asthma, to Lead Development of THB001

Cambridge, Mass. –(BUSINESSWIRE)—June 6, 2022 – Third Harmonic Bio, a clinical-stage biopharmaceutical company developing a potent, highly selective, oral KIT inhibitor for the treatment of severe allergy and inflammation, today announced the appointment of Edward R. Conner, M.D., to chief medical officer (CMO). Dr. Conner brings to the Company extensive experience in clinical development, translational medicine and clinical strategy, with broad experience in early- to late-stage and post-marketing products. As CMO, Dr. Conner will oversee the clinical development strategy for the Company’s lead product candidate, THB001, a potent, highly selective, oral small molecule wild-type KIT inhibitor in clinical development for the treatment of chronic urticaria.

“Ed’s proven track record of developing medicines across multiple therapeutic areas, including allergy and inflammation, will be instrumental as we advance THB001 through clinical development and expand our pipeline beyond our initial indication of chronic urticaria,” said Natalie Holles, chief executive officer of Third Harmonic Bio. “I’m thrilled to be working with Ed again given his outstanding clinical development leadership and focus on efficiently building the right capabilities, team and culture.”

Dr. Conner joins Third Harmonic Bio from Locanabio, where he served as chief medical officer. Prior to Locanabio, Dr. Conner was site lead and division head of medical and development for Astellas Gene Therapies (formerly Audentes Therapeutics). Prior to Astellas’ acquisition of Audentes, he served as CMO and senior vice president of Audentes Therapeutics, where he led functions including clinical development and operations, medical affairs, regulatory, drug safety and patient advocacy. Before Audentes, Dr. Conner served as chief medical officer of Sangamo Therapeutics. Earlier in his career, he was a medical director at Genentech, Inc. (now a member of the Roche Group) where he led clinical development programs for XOLAIR^® (omalizumab) for the treatment of chronic urticaria and allergic asthma.

“Third Harmonic Bio has a significant opportunity to improve the lives of patients living with chronic urticaria, a severe inflammatory skin condition in which currently available therapies do not sufficiently control the disease for many patients, and no new treatment options have been approved in several years,” said Edward R. Conner, M.D., chief medical officer of Third Harmonic Bio. “I’m excited to advance this new investigational medicine through the clinic and explore additional development opportunities across a range of other indications where THB001 may provide benefit to patients living with mast cell-driven inflammatory diseases.”

Dr. Conner earned a medical degree from the University of California, San Francisco, completed his residency in internal medicine at the University of Michigan and his fellowship in clinical immunology and allergic diseases at Johns Hopkins School of Medicine. He earned a bachelor of science degree in biology from Duke University.

About Third Harmonic Bio

Third Harmonic Bio is a clinical-stage biopharmaceutical company focused on advancing the next wave of medicine for allergy and inflammation. The company’s lead product candidate, THB001, is a highly selective, oral small-molecule inhibitor of KIT, a cell surface receptor that serves as the master regulator of mast cell function and survival. The company is in Phase 1a clinical trial in healthy volunteer for THB001 and anticipates initiating a Phase 1b proof-of-concept study in cold-inducible urticaria during the second half of 2022. With promising drug-like properties and an encouraging early clinical profile, THB001 has the potential to revolutionize the treatment of a broad range of dermatologic, respiratory and gastrointestinal allergic and mast-cell-mediated inflammatory diseases. Visit ThirdHarmonicBio.com or follow us on Twitter or LinkedIn to learn more about our work, team, and culture.

Media Contact:
Lori Murray

lori.murray@captivate-comms.com

Investor Contact:
Bob Ho
rho@thirdharmonicbio.com

XOLAIR^® is a registered trademark of Novartis AG.

CAMBRIDGE, Mass., April 6, 2022, Third Harmonic Bio, a clinical-stage company developing a first-in-class, highly selective, oral KIT inhibitor for the treatment of severe allergy and inflammation, announced today the appointment of Adrian S. Ray, Ph.D., as Chief Scientific Officer.

“We’re very excited to welcome Adrian to Third Harmonic Bio,” said Natalie Holles, Chief Executive Officer of Third Harmonic Bio. “Adrian is a highly skilled and experienced drug developer, with an outstanding track record and a highly relevant skill set in the development of small molecules for inflammatory diseases. He will oversee all aspects of nonclinical development for our lead program, THB001, as well as our ongoing discovery and optimization work in the oral KIT inhibitor space.”

Adrian joins Third Harmonic Bio with more than 25 years of scientific and biotech industry experience, with a focus on the discovery and clinical translation of transformative medications from target selection to registrational filing. Before joining Third Harmonic Bio, he served as Senior Vice President Biology and Translation at Morphic Therapeutic, where he built the translation function and shaped the discovery pipeline in fibrosis, immunology, and oncology. Earlier, Adrian spent 15 years at Gilead Sciences, where he held positions of increasing responsibility in research and development. He has directly contributed to regulatory filings including over a dozen IND and NDA filings across therapeutic areas. He has published over 100 peer-reviewed papers and is an inventor on over 30 U.S.-granted patents. Adrian graduated with highest honors from the University of California, Santa Cruz, with a B.A. in molecular, cellular, and developmental biology and received his Ph.D. for his work in the pharmacology department at Yale University.

“I’m excited to join the team at Third Harmonic Bio as we work to advance THB001 for the treatment of chronic urticaria and other mast-cell driven inflammatory and allergic diseases,” said Dr. Ray. “Contributing to the advancement of a novel therapeutic approach in KIT inhibition for a range of diseases with high unmet needs is a unique opportunity. I’m inspired by the passion of the team and the magnitude of our potential impact on the field.”

About THB001
Third Harmonic Bio’s lead program, THB001, is a first-in-class, oral small-molecule inhibitor of wild-type KIT, a cell surface receptor that serves as the master regulator of mast cell function and survival. When activated by a range of stimuli, mast cells trigger the inflammatory responses associated with the symptoms of severe allergic diseases. THB001 is currently in a Phase 1 healthy volunteer study. The company anticipates initiating a Phase 1b proof-of-concept study in cold-inducible urticaria in the second half of 2022. Beyond chronic urticaria, the company plans to develop THB001 in other skin, airway, and gastrointestinal tract diseases in which mast cells play a central pathophysiologic role.

About Third Harmonic Bio

Third Harmonic Bio is a clinical-stage company developing a first-in-class, highly selective, oral KIT inhibitor for the treatment of severe allergy and inflammation. KIT is a cell surface receptor that acts as the master survival and functional regulator of mast cells, which are immune cells concentrated at the body’s interfaces with the external environment and act as the key mediator of the inflammation associated with allergic diseases. Our lead product candidate, THB001, is the first highly selective, oral small-molecule KIT inhibitor to enter clinical development. With promising drug-like properties and an encouraging early clinical profile, THB001 has the potential to revolutionize the treatment of a broad range of dermatologic, respiratory, and gastrointestinal allergic and mast-cell mediated inflammatory diseases. Visit ThirdHarmonicBio.com or follow us on Twitter or LinkedIn to learn more about our work, team, and culture.

Media Contact:
Michele Rozen
mrozen@scientpr.com

Investor Contact:
Bob Ho
rho@thirdharmonicbio.com

CAMBRIDGE, Mass., March 9, 2022, Third Harmonic Bio, a clinical-stage company developing a first-in-class, highly selective, oral KIT inhibitor for the treatment of severe allergy and inflammation, announced today the appointment of Robert Ho as Chief Financial Officer. 

“We are delighted to welcome Bob to the Third Harmonic team,” said Natalie Holles, Chief Executive Officer of Third Harmonic Bio. “Bob’s extensive experience in capital markets, finance operations, and strategy will bring a vital perspective to our work as we advance our lead program THB001 further into clinical development, scale our organization, and build a great company.”

Bob joins Third Harmonic from Neoleukin Therapeutics, Inc., a publicly held biopharmaceutical, where he served as Chief Financial Officer and oversaw finance, information technology, and business operations. Previously, Bob was a Vice President in the Investment Banking Division of Morgan Stanley & Co., where he advised companies on financing and strategic matters. In this role, he successfully executed more than $9 billion in financings and participated in the completion of more than $5 billion in M&A transactions. Bob also served as a Senior Finance Director at Davita, Inc., a leading provider of kidney dialysis services. He received his B.B.A. in accountancy and computer applications from the University of Notre Dame and his M.B.A. from the University of Virginia Darden School of Business.

“I’m excited to join Third Harmonic at such a transformative time for the company,” said Bob Ho. “The pipeline-in-a-product potential of THB001 to provide meaningful benefits to patients, the passionate culture of the team, and the opportunity to build value for our stakeholders energize me. I can’t wait to get started.” 

Third Harmonic Bio’s lead program, THB001, is a first-in-class, oral small-molecule inhibitor of KIT, a cell surface receptor that serves as the master regulator of mast cell function and survival. When activated by a range of stimuli, mast cells trigger the inflammatory responses associated with the symptoms of dermal, airway, and gastrointestinal allergic diseases. THB001 is currently in a Phase 1 healthy volunteer study, and the company anticipates initiating a Phase 1b proof-of-concept study in cold-inducible urticaria in the second half of 2022. Beyond chronic urticaria, the company plans to develop THB001 in other skin, airway, and gastrointestinal tract diseases in which mast cells play a central pathophysiologic role.

About Third Harmonic Bio

Third Harmonic Bio is a clinical-stage company developing a first-in-class, highly selective, oral KIT inhibitor for the treatment of severe allergy and inflammation. KIT is a cell surface receptor that acts as the master survival and functional regulator of mast cells, which are immune cells concentrated at the body’s interfaces with the external environment and act as the key mediator of the inflammation associated with allergic diseases. Our lead product candidate, THB001, is the first highly selective, oral small-molecule KIT inhibitor to enter clinical development. With promising drug-like properties and an encouraging early clinical profile, THB001 has the potential to revolutionize the treatment of a broad range of dermatologic, respiratory, and gastrointestinal allergic and mast-cell mediated inflammatory diseases. Visit ThirdHarmonicBio.com or follow us on Twitter or LinkedIn to learn more about our work, team, and culture.

Media Contact:
Michele Rozen
mrozen@scientpr.com

Investor Contact: 
Bob Ho
ho@thirdharmonicbio.com

• Lead Program, THB001, a First-In-Class, Highly Selective, Oral KIT Inhibitor in Development for Multiple Allergic and Inflammatory Conditions, Is Currently in Phase 1 Clinical Development
• $155 Million Raised to Date Expected to Fund Operations Beyond Completion of a Proof-of-Concept Study in Chronic Urticaria
• Experienced Management Team Is Led by Natalie Holles, CEO, Stephen Yoo, M.D., CMO, and Howard Davis, Ph.D., COO

CAMBRIDGE, Mass., February 16, 2022 – Third Harmonic Bio, a clinical-stage company developing a first-in-class, highly selective, oral KIT inhibitor for treatment of severe allergy and inflammation, launched today with the close of a Series B financing that brings the total capital raised to date to $155 million. This is expected to fund development of the company’s lead candidate, THB001, through the next phase of human studies for the initial indication of chronic urticaria. Atlas Venture founded and seeded Third Harmonic Bio in 2019 and co-led the $50 million Series A with OrbiMed with participation from BVF Partners. Atlas and OrbiMed also participated in the $105 million Series B, which was led by new investor General Atlantic and co-led by existing investor BVF Partners. Additional new investors in the round included Boxer Capital, RA Capital, RTW, Deep Track Capital, Ajax Health/Zeus, and Commodore Capital.

THB001 is a first-in-class, oral small-molecule inhibitor of KIT, a cell surface receptor that serves as the master regulator of mast cell function and survival. Mast cells localize at the body’s interfaces with the external environment, and when activated by a range of stimuli, trigger the inflammatory responses that are associated with the symptoms of dermal, airway, and gastrointestinal allergic diseases. Given its function, inhibiting KIT has the potential to blunt mast cell-driven inflammation regardless of the activating signal source, providing the potential for broad therapeutic utility.

In extensive preclinical studies, THB001 has demonstrated promising drug-like properties, excellent kinome selectivity, and potent mast cell depletion activity in all relevant tissue types. In early clinical studies, THB001 demonstrated robust pharmacodynamic effects, as measured by serum tryptase, an established marker of mast cell activity and survival. The company anticipates initiating a Phase 1b proof-of-concept study in cold-inducible urticaria in the second half of 2022.

“Achieving the selectivity required to target KIT with an oral small-molecule therapy for allergy and inflammation has until now been an intractable drug development challenge,” said Natalie Holles, Chief Executive Officer of Third Harmonic Bio. “As a first-in-class, highly selective KIT inhibitor, we believe THB001 has the potential to revolutionize the treatment of a broad range of mast cell-mediated allergic and inflammatory diseases of the skin, airway, and GI tract.”

“Allergic and inflammatory diseases represent a significant unmet medical need, and although available therapies have been commercially successful, only a fraction of the diagnosed patient population is adequately treated,” said Rob Perez, Operating Partner at General Atlantic. “THB001, with its unique attributes and oral formulation, represents a true pipeline-in-a-product opportunity with the potential to offer an important new therapeutic option to millions of underserved patients.”

“We are excited to continue to support Third Harmonic Bio’s fantastic team in bringing a powerful new potential medicine to patients affected by diverse mast cell-driven diseases,” said Michael Gladstone, Partner at Atlas Venture and Third Harmonic Bio founder. “We are delighted to partner with Third Harmonic Bio’s new investors as the company advances and expands the THB001 clinical development program.”

THB001 is initially being developed for the treatment of chronic urticaria, a dermatologic disease driven by mast cell activation that results in red, itchy, painful welts or hives that develop in response to a specific stimulus (inducible urticaria) or with no known cause (spontaneous or idiopathic urticaria). Up to one percent of the U.S. population is believed to be affected by chronic urticaria at some point in their lives. Standard first-line treatment with oral antihistamines is only effective in approximately half of urticaria patients. Beyond antihistamines, injectable biologic therapy is the only approved second-line treatment option and provides complete relief to less than half of all patients. It is estimated that up to 90% of urticaria patients who have failed antihistamine therapy either fail or forgo biologic therapy, leaving tremendous unmet need in a disease with meaningful impacts on mental well-being and quality of life.

Beyond chronic urticaria, the company plans to pursue development of THB001 in additional diseases of the skin, airway, and gastrointestinal tract in which mast cells play a known role in the pathophysiology of the condition.

Leadership Team

Third Harmonic Bio is led by an outstanding executive team with diverse backgrounds in the critical functions required for successful drug development and company building, as well as a demonstrated track record of successful value creation.

Third Harmonic Bio is led by Natalie Holles, Chief Executive Officer; Stephen Yoo, M.D., Chief Medical Officer; and Howard Davis, Ph.D., Chief Operating Officer.

The company’s Board of Directors comprises David Bonita, M.D., General Partner, OrbiMed; Michael Gladstone, Partner, Atlas Venture; Natalie Holles, Chief Executive Officer; Mark Iwicki (Chairman), Chief Executive Officer, Kala Therapeutics; Shao-Lee Lin, M.D., Ph.D., Chief Executive Officer, Acelyrin, Inc.; Rob Perez, Operating Partner, General Atlantic; Jason Rhodes, Partner, Atlas Venture; and Martin Seidel, Ph.D., Chief Executive Officer, IFM Therapeutics.

About Third Harmonic Bio

Third Harmonic Bio is a clinical-stage company developing a first-in-class, highly selective, oral KIT inhibitor for treatment of severe allergy and inflammation. KIT is a cell surface receptor that acts as the master survival and functional regulator of mast cells, which are immune cells concentrated at the body’s interfaces with the external environment and that act as the key mediator of the inflammation associated with allergic diseases. Our lead product candidate, THB001, is the first highly selective, oral small-molecule KIT inhibitor to enter clinical development. With promising drug-like properties and an encouraging early clinical profile, THB001 has the potential to revolutionize the treatment of a broad range of dermatologic, respiratory, and gastrointestinal allergic and mast-cell mediated inflammatory diseases. Visit ThirdHarmonicBio.com or follow us on Twitter or LinkedIn to learn more about our work, our team, and our culture.

Contact:
Michele Rozen
mrozen@scientpr.com